The evolution of dentistry has an increasing need for the creation of new materials that facilitate postoperative adversities, such as pain and edema experienced by patients. The leukocyte and platelet-rich fibrin membrane (L-PRF) is an example of platelet concentrates that presents a preparation process from a patient's own blood sample, which is subjected to a specific centrifugation procedure, which results in a fibrin membrane, rich in leukocytes and growth factors. L-PRF has been used with the promise of improving tissue healing and reducing the inflammatory process after third molar extractions. Based on this utility, this study aimed to review the literature on the use of L-PRF in the post-extraction alveolus and seek an answer to the research question: What are the effects and how  leukocyte and platelet-rich fibrin membrane (L -PRF) has been used in post-extraction alveolus? Studies in Pubmed, Cochrane and Google Scholar were searched. Based on the 4 studies included, the use of L-PRF after third molar extractions significantly reduces the risk of alveolar osteitis, and has a positive effect on pain, trismus and edema. And also L-PRF when combined with HA (hyaluronic acid), can be used to minimize post-operative edema after mandibular third molar surgery.